Buschke-Löwenstein tumor (BLT), or giant condyloma acuminatum, is a rare, locally aggressive, but histologically benign fibroepithelial tumor caused by the human papillomavirus (HPV) [1]. While surgical excision remains the gold standard, it can be invasive and carries risks of recurrence. We present the case of a 28-year-old unmarried female with an extensive anogenital BLT and a history of Hepatitis B. Due to the patient's young age, unmarried status, and significant cosmetic concerns, a non-surgical approach was preferred. She was treated with a combination of weekly topical 20% podophyllin and oral isotretinoin. Complete clinical clearance was achieved over six months.