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Research Article | Volume 5 Issue 1 (None, 2011) | Pages 5 - 7
Pyogenic granulomas during isotretinoin therapy
 ,
Under a Creative Commons license
Open Access
PMID : PMC3163353
Received
June 13, 2010
Published
March 26, 2011
Abstract

Background:A review of scientific literature reveals a sparse documentation of periungual pyogenic granulomas as an adverse effect of isotretinoin therapyMain observations:Periungual pyogenic granulomas appeared in four patients receiving isotretinoin therapy for severe acne. Oral and topical antibiotic treatments were ineffective and all cases spontaneously resolved once isotretinoin is discontinued.Conclusion:This report demonstrates the idiosyncratic nature of this side effect. We suggest that, although infection is possible due to the transformed nature of the normally protective skin barrier, oral and topical antibiotic treatments appear ineffective. Pyogenic granulomas spontaneously resolve once isotretinoin is discontinued.

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