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Research Article | Volume 10 Issue 2 (None, 2016) | Pages 42 - 45
Pigmented colloid milium associated with exogenous ochronosis in a farmer with long-term exposure to fertilizers
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Under a Creative Commons license
Open Access
PMID : PMC4517802
Received
Aug. 15, 2011
Published
June 30, 2015
Abstract

Background:Colloid milium is a rare cutaneous deposition disorder characterized by translucent papules developing on sun-exposed regions such as the face, neck and dorsal aspects of the hands and back. Exogenous ochronosis is caused by the accumulation of homogentisic acid resulting from long-term application of certain topical agents. Histology is characterized by yellow-brown pigment deposits in the papillary dermis. Prolonged use of hydroquinone may result in the development of the pigmented form of colloid milium, sometimes in association with ochronosis.Case report:A 53-year-old man presented with a 3-year history of multiple slow spreading pigmented papules on the dorsa of his hands, nose and ears. The patient had a long history of exposure to sun and fertilizers with no history of using hydroquinone bleaching creams. A later biopsy revealed the diagnosis of pigmented colloid milium associated with exogenous ochronosis.Conclusion:UV light damage and long contact with fertilizers may have a role in the development of pigmented colloid milium associated with exogenous ochronosis.

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