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Research Article | Volume 7 Issue 2 (None, 2013) | Pages 69 - 70
Photoletter to the editor - Calciphylaxis: a diagnostic and therapeutic challenge
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Under a Creative Commons license
Open Access
PMID : PMC3710683
Received
Nov. 20, 2012
Published
June 30, 2013
Abstract

Calciphylaxis is an uncommon necrotizing dermal condition, most often related to end-stage renal disease, associated with secondary hyperparathyroidism. The incidence is 1-4% per year in dialyzed patients. The condition is characterized by microcalcification of small and medium-sized blood vessels, causing cutaneous and soft tissue necrosis. The etiology of calciphylaxis is poorly understood, although many reports highlight the abnormal calcium-phosphate products as an important etiological factor. Calciphylaxis is associated with significant morbidity and mortality with estimated 5-year survival rates of less than 50%. Sepsis is the main cause of death. We report two patients of calciphylaxis treated with surgical debridement and excellent outcome in both cases.

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