Hailey-Hailey disease treated with methotrexate

doi:10.3315/jdcr.2012.1098

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Research Article | Volume 6 Issue 2 (None, 2012) | Pages 49 - 51

Hailey-Hailey disease treated with methotrexate

Antonietta D’Errico

Diletta Bonciani

Veronica Bonciolini

Alice Verdelli

Emiliano Antiga

Paolo Fabbri

Marzia Caproni

Under a Creative Commons license

Open Access

DOI : 10.3315/jdcr.2012.1098

PMID : PMC3399676

Received

March 12, 2012

Published

June 30, 2012

Abstract

Background:Hailey-Hailey disease (HHD) is a chronic, recurrent blistering disorder characterized clinically by erosions occurring primarily in intertriginous regions and histologically by suprabasal acantholysis.Mainobservations:We report a long standing case of HHD initially unresponsive to cyclosporin, multiple topical and systemic steroids. Good response was achieved with methotrexate 7,5 mg weekly for 16 week, intramuscularly, and topical steroids as needed.Conclusion:In conclusion, we suggest that methotrexate could be considered a therapeutic option for the treatment of HHD and in particular as a maintaining therapy to control the disease flares.

Keywords

Hailey-Hailey disease

Methotrexate

Pemphigus

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