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Research Article | Volume 6 Issue 2 (None, 2012) | Pages 49 - 51
Hailey-Hailey disease treated with methotrexate
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Under a Creative Commons license
Open Access
PMID : PMC3399676
Received
March 12, 2012
Published
June 30, 2012
Abstract

Background:Hailey-Hailey disease (HHD) is a chronic, recurrent blistering disorder characterized clinically by erosions occurring primarily in intertriginous regions and histologically by suprabasal acantholysis.Mainobservations:We report a long standing case of HHD initially unresponsive to cyclosporin, multiple topical and systemic steroids. Good response was achieved with methotrexate 7,5 mg weekly for 16 week, intramuscularly, and topical steroids as needed.Conclusion:In conclusion, we suggest that methotrexate could be considered a therapeutic option for the treatment of HHD and in particular as a maintaining therapy to control the disease flares.

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