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Research Article | Volume 6 Issue 4 (None, 2012) | Pages 108 - 112
Granulomatous slack skin. Histopathology diagnosis preceding clinical manifestations by 12 years.
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Under a Creative Commons license
Open Access
PMID : PMC3543856
Received
Nov. 12, 2012
Published
Dec. 31, 2012
Abstract

Background:Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing.Main observation:We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease’s characteristic clinical presentation appeared.Conclusions:During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.

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