Background:Secondary erythromelalgia can occur due to various underlying medical disorders or drug toxicity.Main observations:A 75-year old male developed acute secondary erythromelalgia following the onset of rosuvastatin use and associated myopathy. The illness was reversible after discontinuation of the pharmacological agent.Conclusion:Secondary erythromelalgia may occur after rosuvastatin use, but this and other dermatological toxicities are rare.