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Research Article | Volume 6 Issue 4 (None, 2012) | Pages 117 - 119
Drug-induced linear IgA bullous dermatosis after discontinuation of cefuroxime axetil treatment
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Under a Creative Commons license
Open Access
PMID : PMC3543858
Received
Oct. 17, 2012
Published
Dec. 31, 2012
Abstract

Background:Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune blistering disorder. The disease may be either idiopathic or druginduced. Over the past 30 years, approximately one hundred LABD cases have been described as induced by a wide range of drugs, chiefly antibiotics.Main observations: We report the case of 37-year-old woman who developed pruritic bullous lesions spread all over the body three weeks after her last dose of cefuroxime axetil. Antibiotic therapy was started due to rhino-sinusitis.Conclusions:In most reported cases of drug-induced LABD, skin lesions occur within the time of drug administration. However, the onset of disease may be even after discontinuation of treatment. It seems that in such cases, other clinical conditions (like infection) act, as cofactors of immunologic response.

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