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Research Article | Volume 19 Issue 3 (Jul, 2026) | Pages 16 - 21
Delayed Bullous Pressure Urticaria in a Female Patient: A Rare Clinical Presentation and Therapeutic Challenge
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1
Department of Internal Diseases, Allergology, Endocrinology and Gastroenterology, Institute of Medical Sciences, University of Opole, Opole, Poland.
2
Students’ Scientific Association “Alergos”, Institute of Medical Sciences, University of Opole, Opole, Poland
Under a Creative Commons license
Open Access
Received
June 13, 2026
Revised
July 8, 2026
Accepted
July 11, 2026
Published
July 15, 2026
Abstract

Delayed pressure urticaria usually presents with painful swelling after sustained mechanical pressure, whereas frank blistering is exceptional. We report a 44-year-old woman with a more than 10-year history of recurrent pressure-induced oedema, angioedema, and bullous lesions, with marked worsening over the preceding two years. During hospitalization, erythematous-oedematous changes on the right forearm evolved into tense serous bullae after mechanical loading, supporting that this was not typical pressure urticaria but a bullous variant. Diagnostic evaluation excluded several alternative causes of blistering, including autoimmune bullous disease, and provocation testing confirmed delayed pressure urticaria together with symptomatic dermographism. Because the patient declined skin biopsy, the diagnosis relied on the characteristic pressure dependence of lesions, supportive provocation testing, and clinical response. The patient improved with short-term systemic corticosteroids and high-dose bilastine, and long-term disease control was subsequently achieved with gradual antihistamine dose adjustment and structured follow-up using UCT and AECT assessments. This case highlights delayed bullous pressure urticaria as a rare and potentially misleading presentation of chronic inducible urticaria, underscores the need to distinguish it from more common oedematous forms of pressure urticaria and from primary bullous dermatoses, and emphasizes early recognition, trigger avoidance, and minimization of prolonged corticosteroid exposure.

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