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Research Article | Volume 8 Issue 3 (None, 2014) | Pages 70 - 74
Cutaneous mastocytosis combined with eruptive melanocytic nevi and melanoma. Coincidence or a linkage in the pathogenesis?
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Under a Creative Commons license
Open Access
PMID : PMC4195503
Received
May 5, 2014
Published
Sept. 30, 2014
Abstract

Background:Cellular combinations in the same neoplasm can have intriguing physiopathological implications, which may be useful to better understand the biology of the diseases.Main observations:Urticaria pigmentosa in association with eruptive melanocytic nevi was observed in a female patient. Maculopapular lesions extended at the base of different melanocytic nevi and the histopathological examination revealed the presence of a mast cell population in the papillary and reticular dermis combined with overlying melanocytic nevi. The re-evaluation of a melanoma removed three years before revealed the presence of the same pathological features. Immunohistochemical assays showed a strong positivity to Giemsa, Toluidine blue and CD-117 in the mast cells, while a S-100 reaction was observed in the melanocytic population.Conclusions:We discuss possible pathogenetic linkage between cutaneous mastocytosis and melanoma.

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