Background: Acne vulgaris is a common dermatological condition with multifactorial etiology, including hormonal, metabolic, and inflammatory factors. Emerging evidence suggests that lipid profile abnormalities and altered liver function may play a role in the pathogenesis or progression of acne.

Objective: To evaluate the correlation between lipid profiles, liver function tests (LFTs), and the severity of acne vulgaris.

Methods: A cross-sectional study was conducted on 100 patients diagnosed with acne vulgaris and 50 age- and sex-matched healthy controls. Lipid profile (Total cholesterol, HDL, LDL, Triglycerides) and LFTs (ALT, AST, ALP, and Total bilirubin) were measured. Acne severity was graded using the Global Acne Grading System (GAGS).

Results: Acne patients exhibited significantly elevated triglycerides (p<0.001), LDL (p=0.004), and reduced HDL (p=0.006) compared to controls. Mild elevations in ALT and ALP were noted in moderate-to-severe acne patients. A positive correlation was found between acne severity and triglyceride levels (r=0.49), while a negative correlation was observed with HDL (r=-0.35).

Conclusion: Alterations in lipid metabolism and mild liver dysfunction may contribute to the pathogenesis and severity of acne vulgaris. Monitoring these parameters may be beneficial for holistic acne management.