Introduction: Vitiligo is an acquired pigmentary disorder of unknown origin that poses not just cosmetic concerns but presents a major psychological burden due to its visible and chronic nature. It often leads to stigmatization, poor self-image, and psychiatric comorbidities like depression and anxiety. Despite the high psychological impact, there is a paucity of literature from North India assessing these mental health outcomes in vitiligo patients.

Objective: To assess the prevalence and severity of anxiety and depression in patients with vitiligo and explore its association with disease severity and quality of life (QOL).

Methods: A cross-sectional study was conducted on 40 vitiligo patients at a tertiary care hospital in North India. The Vitiligo Area Severity Index (VASI) was used to measure disease severity. The Hamilton Depression Rating Scale (HAM-D) and Hamilton Anxiety Rating Scale (HAM-A) were used for psychological assessments, and WHOQOL-BREF was used for evaluating QoL. Statistical analysis included descriptive data, Pearson correlations, and group comparisons.

Results: 50% of patients had mild depression, 30% moderate, and 5% severe. 62.5% had clinically significant anxiety symptoms. VASI showed a significant positive correlation with both HAM-A and HAM-D scores (p < 0.05) and a negative correlation with WHOQOL-BREF domains, especially psychological and social health. Unmarried participants had significantly higher levels of depression and anxiety than married ones (p < 0.05). No significant gender differences were noted.

Conclusion: Vitiligo significantly compromises psychological well-being and quality of life, especially in patients with greater disease severity. Routine mental health screening and a multidisciplinary treatment approach are strongly recommended for holistic care.