Background/Aim: Erythroderma, a severe inflammatory skin disorder marked by widespread erythema and scaling, poses significant diagnostic and therapeutic challenges. Thus, this study aimed to assess epidemiological parameters, etiology, clinical features, and disease progression in erythroderma among a total of 73 inpatient and outpatient cases, utilizing parameters such as patient complaints, medical history, addictions, and general/cutaneous and nail examinations.

Results: We found a geriatric predominance (64.38% of cases aged >50 years) and identified psoriasis as the primary etiology (54.29%). The scalp and trunk were the most common sites of onset (31.49% combined). Systemic features included edema (30.13%) and lymphadenopathy (27.4%), while nail changes prominently featured onycholysis (40%). Central obesity risks were significant (female waist ≥88 cm: 88%). Addictions (tobacco 47.9%) and comorbidities (HTN 24.65%, DM 17.80%) drove disease progression.

Conclusion: Integrated dermatologic-metabolic management targeting modifiable risks is crucial to mitigate erythroderma severity and recurrence.