Background & Methods: The aim of the study is to study Randomized Controlled Trial Comparing the Efficacy & Safety of Oral Colchicine versus Oral Isotretinoin in the Treatment of Lichen Planus Pigmentosus. Lichen Planus Pigmentosus (LPP) is a chronic pigmentary disorder with limited therapeutic options. Oral isotretinoin & colchicine have been reported to have beneficial effects, but head-to-head comparisons are lacking.

Results: Both groups showed significant improvement in pigmentation. The colchicine group showed a higher rate of marked improvement (≥75% reduction in pigmentation score) compared to isotretinoin (48% vs. 32%, p = 0.04). Adverse effects were mild in both groups, though mucocutaneous dryness was more frequent in the isotretinoin group.

Conclusion: Oral colchicine is a safe & more effective alternative to isotretinoin in treating LPP.